Judd Gregg has dropped out as a candidate for Commerce Secretary because of disputes with President Obama over how to handle the 2010 Census. The issue has to do with how to count people with Obama wanting to use a modeling technique that would try to account for people who are missed in the count.
This has long been controversial because it does basically involve guessing about the numbers of people and most of the models tend to increase the counts in largely Democratic areas like big cities at the expense of more Republican oriented rural regions. Since the Census determines House membership it is obviously a touchy subject.