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Swine Flu Update & Planning

UPDATE: ScienceBlogs:

There will be an update from CDC later today and WHO’s expert committee established under the new International Health Regulations (IHR) meets via teleconference this morning North American east coast time at 10 am (4 pm Geneva time) to consider whether the swine flu situation merits declaring it “a public health event of international concern.” [...]

One of the puzzling things about this outbreak is the stark contrast between the clinical and epidemiological picture in Mexico and the US, with reported Mexican cases winding up on ventilators and dying with severe lower respiratory disease while US cases have been mild with uneventful recoveries

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ScienceBlogs:

Mexican authorities are saying that they have determined that 16 of 60 deaths are “swine flu,” with 44 more being tested. They have yet to confirm whether it is the same as the California/Texas cases, but that’s a bit irrelevant since either way it sounds like a very worrisome development. There are already a reported 930 plus cases, with schools closed in Mexico City and contemplation of closing government offices. Obama has been notified and the White House is following the situation. WHO and CDC have activated their emergency centers and there is consideration at WHO of increasing the pandemic alert level.

Things are changing too fast for any reasonable speculation at this point.

NYTimes:Image Hosted by ImageShack.us

The new strain contains gene sequences from North American and Eurasian swine flus, North American bird flu and North American human flu, said the Centers for Disease Control and Prevention. [...]

Because of the situation, the World Health Organization planned to consider raising the world pandemic flu alert to 4 from 3. Such a high level of alert — meaning that sustained human-to-human transmission of a new virus has been detected — has not been reached in recent years, even with the H5N1 avian flu circulating in Asia and Egypt, and would “really raise the hackles of everyone around the world,” said Dr. Robert G. Webster, a flu virus expert at St. Jude Children’s Research Hospital in Memphis.

CNN, we’re due:

A pandemic is defined as: a new virus to which everybody is susceptible; the ability to readily spread from person to person; and the capability of causing significant disease in humans, said Dr. Jay Steinberg, an infectious disease specialist at Emory University Hospital Midtown in Atlanta. The new strain of swine flu meets only one of the criteria: novelty.

History indicates that flu pandemics tend to occur once every 20 years or so, so we’re due for one, Steinberg said.

“I can say with 100 percent confidence that a pandemic of a new flu strain will spread in humans,” he said. “What I can’t say is when it will occur.”

WaPo:

President Obama has been briefed about the illness, spokesman Reid Cherlin said, adding: “The White House is taking the situation seriously and monitoring for any new developments.”

The illness appeared to be primarily striking young, healthy adults, a highly unusual pattern that conjured images of the devastating 1918 flu pandemic.

The US and Mexican flu strains match.

Tamiflu works, as does Relenza. Flu is spread by coughs and sneezes. Smart prevention: WASH YOUR HANDS!

Resources to be aware of: FluWikipandemicflu.gov. CDC Human Swine Influenza Investigation. And getpandemicready.org:

We recommend each household have three months of food, water (or purification capability), medications, and basic supplies on hand. Why Three Months?

On the morning shows today they’re saying we are prepared because we have been planning for a pandemic for years. But in 2007 when the CDC issued its guidelines I went to a session here in Georgia. In this state with over 8 million people we had only 22,000 hospital beds. And 16,800 nurses. The regional official hosting the session told us to stock up and get prepared now because when it hits (not if it hits) all bets are off. We’re on our own.

The community mitigation plan as reported on its 2007 release:

The chief strategy is to keep people physically apart as much as possible during the eight-to-10-week-long waves of illness.

States and metropolitan areas would decide when to invoke various measures, such as closing schools and banning concerts and sporting events. The guidance, notably, did not suggest restricting travel. Its authors believe that if a pandemic’s effects can be blunted or spread out over time, the essential functions of the economy may be able to continue largely unchanged. [...]

Pandemic America would be an old-fashioned place. People would spend most of their time with close relatives and a few neighbors. They wouldn’t go to the movies, run to the supermarket on a whim, or hug people they barely know. The sick would be cared for at home unless they were near death. Everyone would shun the houses of the ill.

At the same time, many of today’s habits and capabilities would remain.

  • kathyedits
    This is very scary.
  • A friend of mine was cured of West Nile virus in 2 days using intravenous vitamin C. Should you be unfortunate and contract swine flu, bird flu or other serious viral disease, you might want to keep this in mind. Since it's generic and nonpatentable, you won't find it in the therapeutic arsenal of mainstream medicine, or in widespread use even in the event of a "pandemic". You can research it online.

    http://www.orthomolecular.org/resources/omns/v0...
  • StockBoySF
    This is scary and thanks, GreenDreams for the link!
  • BigPharma
    Try not to spread misinformation GreenDreams, Vitamin C does not cure West Nile, or any type of flu or virus. Unless you have scurvy there is no reason to have high doses of Vitamin C exept to have your dollars extracted from you from snake oil salesman.

    (Notice that the above article only sites other Orthomecular places and not peer reviewed research, except in the case of scurvy)
    About Vitamin C
    http://bit.ly/118tFm

    About "Orthomolecular Medicine"
    http://en.wikipedia.org/wiki/Orthomolecular_med...
    http://bit.ly/qh7uU
  • I related an anecdote, which is both true and verified by our health department. My friend is over 70 years old and once west nile was confirmed, he was expected to have a very tough time with it. He had a MD administer (from memory, so don't try this at home) 75 grams of vitamin C one day and I believe about twice that the next.

    A physician friend, working in Asia, has found it effective against bird flu, in humans.

    Don't be so sure, big pharma, You've been wrong before.
  • mlhradio
    It is quite disconcerting that as a preventative measure, the closed a high school a few miles up the road for an entire week - as a preventative measure because two of the (currently) eleven confirmed cases in the US happened there. I'm sure that there are plenty of people in town that are positively freaking out already, chicken little style.

    ...And the nutcases are already coming out of the woodwork. My favorite unnecessarily-political comment in the local paper this afternoon: "The idiocRAT lieberals are going to kill us all. Open the borders so the pestilence can spring forth upon America. Impeach Obama NOW!!!!!!!!!!!!" Yeah....riiiiiiggghht.

    Conspiracy theories are abounding. Another comment: "On this flu, it is clearly genetically engineered since it uses genes from three diverse sources (birds, monkey, pigs?). It is a man-made virus that has been created for malicious purposes. Where is USARNORTH, are they not the 'vanguards' to 'save' and 'protect' US citizens from this mess? Or, is this a trial run of Bird Flu at this school?" More conspiracy - here's a recording of a caller to a radio program talking in detail about the DHS transporting the bird flu by truck: http://www.youtube.com/watch?v=_qJQCJp4ehc . And lots of people are making hay that the first person to die in Mexico from the swine flu last week was greeted by Obama the day before: http://www.bloomberg.com/apps/news?pid=20601087...

    I suppose the conspiracy theory nuts jumping on the story is totally inevitable, considering how information spreads through the web with such alacrity these days - but putting the alarm aside it is quite entertaining to watch the rumor mill spread.
  • CStanley
    GD, I gotta mention that not only is an anecdote just an anecdote (not evidence), but also the West Nile Virus is a very different pathogen than a highly virulent strain of influenza. WNV isn't a strong pathogen unless you're immune compromised- so that's why immune stimulation might be helpful. But highly pathogenic viruses attack so swiftly that you have to go about treatment in a very different manner.

    Big Pharma may be guilty of a lot of things, but you don't give their researchers enough credit (plus the fact that virology and the research regarding methods to disrupt viral replication is not as subject to the whims of marketing because government health agencies put a good bit of funding into the pot to find ways to deal with pandemics.) The antiviral drugs generally do work against flu viruses, but the problems are going to be in manufacturing and distributing sufficient quantities of them when needed, and in possible acquired resistance to the drugs.
  • Thanks CS. I never claimed the evidence is all in on alternative therapies like high dose vit C. But if I had an active case of ANY viral infection, I'd sure try it. It's safe and doesn't interfere with other treatments. I'm not a crusader on this topic at all. Just want to highlight for readers that there is intriguing news about high dose vitamin C.

    In a clinical trial of vitamin C adjunct to therapy in tetanus in Bangladesh: Tetanus causes 26% of infant mortality there. "All children got conventional therapy, antitetanus serum, sedatives, antibiotics, etc. Additionally, subjects in the experimental group got 1 gram of intravenous vitamin C daily. None of the children in the experimental group died; 74 percent of the children in the control group died. Dramatic benefits for tetanus patients aged 13 to 30 years were also found. Two-day-old chicks receiving fatal doses of strychnine survived with injections of vitamin C.
    [note: tetanus is bacterial, not viral]

    Nat. Acad of Sciences found high dose vitamin C kills cancer cells in the blood, but not normal cells, apparently by increasing hydrogen peroxide in the serum. (IV Hydrogen peroxide therapy is another controversial treatment that may be valuable.)

    About flu vaccine: In a February 2005 issue of the Archives of Internal Medicine, researchers for the National Institute of Allergy and Infectious Diseases compared flu-related mortality among older people to rates of immunization. Their finding: During the past quarter century, immunization rates for the elderly have climbed substantially while the elderly flu-related mortality rate has stayed the same.

    The authors of the research wrote: "We conclude that observational studies substantially overestimate vaccination benefit."

    One of the reasons vitamin C was first investigated for bird flu, is that the symptoms are identical to scurvy, probably indicating that fighting the virus depletes vitamin C in the body.
    There isn't enough research to date to gain FDA approval of high dose vitamin C, but there is more than enough to justify some serious research. However, since our drug approval system is geared exclusively toward patentable monosubstance synthetic chemicals, that probably won't happen here.

    By the way, not sure where you got your information about antiviral effectiveness. In a review of all the research on Tamiflu and Relenza. According to The Lancet, 2006

    "The use of amantadine and rimantadine should be discouraged. Because of their low effectiveness, neuraminidase inhibitors should not be used in seasonal influenza control and should only be used in a serious epidemic or pandemic alongside other public-health measures."
  • tutmosis
    I am a 58 years male and I have been reading about Vitamin C by 28 years. I have found a lot of missunderstanding information and many people talks without trustable scientific and clinical support. Many scientific papers support that some people say things without clinical investigations and scientific evidence.

    I have cured myself of very difficult to cure prostatitis probably because rising my defenses, also all types of viruses illnes and have attacked flu and destroyed it just during incipient symtoms with high doses of Vitamin C, 10 or 15 grams orally per day. I have done this for several years, also with my parents. So far no adverse effects. Vitamine C is being used intravenous to treat many illness including cancer in may countries. The truth is IT WORKS.
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