Senator John McCain (R-AZ) has announced he will oppose the nomination of Judge Sonia Sotomayor to the Supreme Court. McCain indicated that he felt she was too much of a judicial activist. Since he voted against her nomination to the Appeals Court in 1998 this is at least a consistent decision.
What impact it will have on his re-election campaign next year is unclear. On the one hand the move could help calm the hard right of the party who has been upset with him over the years. At the same time there is a large base of Hispanic voters in Arizona who could be upset.
In any case Sotomayor is still going to be confirmed. The current trend seems to indicate only a few Republican votes for Sotomayor and few (if any) Democratic votes against her. This would suggest a tally of 66-34 or so when the vote comes to the floor.